IPI:IPI00414101.4
Protein Information
| Protein | IPI:IPI00414101.4 |
|---|---|
| Gene Symbol | TOP2A |
| Protein Description | Isoform 2 of DNA topoisomerase 2-alpha |
| Sequence Length | 1557 |
| Mwt | 177389.316 Da |
| Sequence | MEVSPLQPVN ENMQVNKIKK NEDAKKRLSV ERIYQKKTQL EHILLRPDTY IGSVELVTQQ MWVYDEDVGI NYREVTFVPG LYKIFDEILV NAADNKQRDP KMSCIRVTID PENNLISIWN NGKGIPVVEH KVEKMYVPAL IFGQLLTSSN YDDDEKKVTG GRNGYGAKLC NIFSTKFTVE TASREYKKMF KQTWMDNMGR AGEMELKPFN GEDYTCITFQ PDLSKFKMQS LDKDIVALMV RRAYDIAGST KDVKVFLNGN KLPVKGFRSY VDMYLKDKLD ETGNSLKVIH EQVNHRWEVC LTMSEKGFQQ ISFVNSIATS KGGRHVDYVA DQIVTKLVDV VKKKNKGGVA VKAHQVKNHM WIFVNALIEN PTFDSQTKEN MTLQPKSFGS TCQLSEKFIK AHLYSRFLID PFFPNMIPNM IFSFSKAAIG CGIVESILNW VKFKAQVQLN KKCSAVKHNR IKGIPKLDDA NDAGGRNSTE CTLILTEGDS AKTLAVSGLG VVGRDKYGVF PLRGKILNVR EASHKQIMEN AEINNIIKIV GLQYKKNYED EDSLKTLRYG KIMIMTDQDQ DGSHIKGLLI NFIHHNWPSL LRHRFLEEFI TPIVKVSKNK QEMAFYSLPE FEEWKSSTPN HKKWKVKYYK GLGTSTSKEA KEYFADMKRH RIQFKYSGPE DDAAISLAFS KKQIDDRKEW LTNFMEDRRQ RKLLGLPEDY LYGQTTTYLT YNDFINKELI LFSNSDNERS IPSMVDGLKP GQRKVLFTCF KRNDKREVKV AQLAGSVAEM SSYHHGEMSL MMTIINLAQN FVGSNNLNLL QPIGQFGTRL HGGKDSASPR YIFTMLSSLA RLLFPPKDDH TLKFLYDDNQ RVEPEWYIPI IPMVLINGAE GIGTGWSCKI PNFDVREIVN NIRRLMDGEE PLPMLPSYKN FKGTIEELAP NQYVISGEVA ILNSTTIEIS ELPVRTWTQT YKEQVLEPML NGTEKTPPLI TDYREYHTDT TVKFVVKMTE EKLAEAERVG LHKVFKLQTS LTCNSMVLFD HVGCLKKYDT VLDILRDFFE LRLKYYGLRK EWLLGMLGAE SAKLNNQARF ILEKIDGKII IENKPKKELI KVLIQRGYDS DPVKAWKEAQ QKVPDEEENE ESDNEKETEK SDSVTDSGPT FNYLLDMPLW YLTKEKKDEL CRLRNEKEQE LDTLKRKSPS DLWKEDLATF IEELEAVEAK EKQDEQVGLP GKGGKAKGKK TQMAEVLPSP RGQRVIPRIT IEMKAEAEKK NKKKIKNENT EGSPQEDGVE LEGLKQRLEK KQKREPGTKT KKQTTLAFKP IKKGKKRNPW SDSESDRSSD ESNFDVPPRE TEPRRAATKT KFTMDLDSDE DFSDFDEKTD DEDFVPSDAS PPKTKTSPKL SNKELKPQKS VVSDLEADDV KGSVPLSSSP PATHFPDETE ITNPVPKKNV TVKKTAAKSQ SSTSTTGAKK RAAPKGTKRD PALNSGVSQK PDPAKTKNRR KRKPSTSDDS DSNFEKIVSK AVTSKKSKGE SDDFHMDFDS AVAPRAKSVR AKKPIKYLEE SDEDDLF |
Modification Site Information
| Site Position | 96 |
|---|---|
| MS/MS spectra | 24 [show] |
| Best localized sequence | K.IFDEILVNAADNK#QR@.D |
| Matching Proteins |
|
| Site Position | 123 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.VTIDPENNLISIWNNGK#GIPVVEHK.V |
| Matching Proteins |
|
| Site Position | 131 |
|---|---|
| MS/MS spectra | 25 [show] |
| Best localized sequence | K.GIPVVEHK#VEK.V |
| Matching Proteins |
|
| Site Position | 156 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.M*YVPALIFGQLLTSSNYDDDEK#K.V |
| Matching Proteins |
|
| Site Position | 278 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.DK#LDETGNSLK.V |
| Matching Proteins |
|
| Site Position | 525 |
|---|---|
| MS/MS spectra | 77 [show] |
| Best localized sequence | R.EASHK#QIMENAEINNIIK.I |
| Matching Proteins |
|
| Site Position | 546 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.K#NYEDEDSLKTLR.Y |
| Matching Proteins |
|
| Site Position | 555 |
|---|---|
| MS/MS spectra | 17 [show] |
| Best localized sequence | K.NYEDEDSLK#TLR.Y |
| Matching Proteins |
|
| Site Position | 561 |
|---|---|
| MS/MS spectra | 12 [show] |
| Best localized sequence | R.YGK#IMIMTDQDQDGSHIK.G |
| Matching Proteins |
|
| Site Position | 605 |
|---|---|
| MS/MS spectra | 30 [show] |
| Best localized sequence | R.FLEEFITPIVK#VSK.N |
| Matching Proteins |
|
| Site Position | 610 |
|---|---|
| MS/MS spectra | 18 [show] |
| Best localized sequence | K.NK#QEMAFYSLPEFEEWK.S |
| Matching Proteins |
|
| Site Position | 648 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | K.GLGTSTSK#EAK.E |
| Matching Proteins |
|
| Site Position | 665 |
|---|---|
| MS/MS spectra | 9 [show] |
| Best localized sequence | R.IQFK#YSGPEDDAAISLAFSK.K |
| Matching Proteins |
|
| Site Position | 681 |
|---|---|
| MS/MS spectra | 54 [show] |
| Best localized sequence | K.YSGPEDDAAISLAFSK#K.Q |
| Matching Proteins |
|
| Site Position | 688 |
|---|---|
| MS/MS spectra | 76 [show] |
| Best localized sequence | R.K#EWLTNFMEDR.R |
| Matching Proteins |
|
| Site Position | 702 |
|---|---|
| MS/MS spectra | 18 [show] |
| Best localized sequence | R.K#LLGLPEDYLYGQTTTYLTYNDFINK.E |
| Matching Proteins |
|
| Site Position | 919 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.LMDGEEPLPMLPSYK#NFK.G |
| Matching Proteins |
|
| Site Position | 962 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | R.TWTQTYK#EQVLEPMLNGTEK.T |
| Matching Proteins |
|
| Site Position | 975 |
|---|---|
| MS/MS spectra | 115 [show] |
| Best localized sequence | K.EQVLEPMLNGTEK#TPPLITDYR.E |
| Matching Proteins |
|
| Site Position | 1088 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | K.IDGK#IIIENKPK.K |
| Matching Proteins |
|
| Site Position | 1185 |
|---|---|
| MS/MS spectra | 10 [show] |
| Best localized sequence | K.EQELDTLK#R@.K |
| Matching Proteins |
|
| Site Position | 1222 |
|---|---|
| MS/MS spectra | 9 [show] |
| Best localized sequence | K.QDEQVGLPGK#GGK.A |
| Matching Proteins |
|
| Site Position | 1230 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | K.K#TQMAEVLPSPR.G |
| Matching Proteins |
|
| Site Position | 1285 |
|---|---|
| MS/MS spectra | 131 [show] |
| Best localized sequence | K.NENTEGSPQEDGVELEGLK#QR.L |
| Matching Proteins |
|