IPI:IPI00879004.1
Protein Information
| Protein | IPI:IPI00879004.1 |
|---|---|
| Gene Symbol | TOP2A |
| Protein Description | Isoform 4 of DNA topoisomerase 2-alpha |
| Sequence Length | 1612 |
| Mwt | 182566.857 Da |
| Sequence | MEVSPLQPVN ENMQVNKIKK NEDAKKRLSV ERIYQKKTQL EHILLRPDTY IGSVELVTQQ MWVYDEDVGI NYREVTFVPG LYKIFDEILV NAADNKQRDP KMSCIRVTID PENNLISIWN NGKGIPVVEH KVEKMYVPAL IFGQLLTSSN YDDDEKKVTG GRNGYGAKLC NIFSTKFTVE TASREYKKMF KQTWMDNMGR AGEMELKPFN GEDYTCITFQ PDLSKFKMQS LDKDIVALMV RRAYDIAGST KDVKVFLNGN KLPVKGFRSY VDMYLKDKLD ETGNSLKVIH EQVNHRWEVC LTMSEKGFQQ ISFVNSIATS KGGRHVDYVA DQIVTKLVDV VKKKNKGGVA VKAHQRELCN GAILAHCNLR LMGSSDSPAS ASRVAGIAGG CHHTQLIFVF LVETGFHHVG QAGLERLTSG DPPASASQSS GITDVKVKNH MWIFVNALIE NPTFDSQTKE NMTLQPKSFG STCQLSEKFI KAAIGCGIVE SILNWVKFKA QVQLNKKCSA VKHNRIKGIP KLDDANDAGG RNSTECTLIL TEGDSAKTLA VSGLGVVGRD KYGVFPLRGK ILNVREASHK QIMENAEINN IIKIVGLQYK KNYEDEDSLK TLRYGKIMIM TDQDQDGSHI KGLLINFIHH NWPSLLRHRF LEEFITPIVK VSKNKQEMAF YSLPEFEEWK SSTPNHKKWK VKYYKGLGTS TSKEAKEYFA DMKRHRIQFK YSGPEDDAAI SLAFSKKQID DRKEWLTNFM EDRRQRKLLG LPEDYLYGQT TTYLTYNDFI NKELILFSNS DNERSIPSMV DGLKPGQRKV LFTCFKRNDK REVKVAQLAG SVAEMSSYHH GEMSLMMTII NLAQNFVGSN NLNLLQPIGQ FGTRLHGGKD SASPRYIFTM LSSLARLLFP PKDDHTLKFL YDDNQRVEPE WYIPIIPMVL INGAEGIGTG WSCKIPNFDV REIVNNIRRL MDGEEPLPML PSYKNFKGTI EELAPNQYVI SGEVAILNST TIEISELPVR TWTQTYKEQV LEPMLNGTEK TPPLITDYRE YHTDTTVKFV VKMTEEKLAE AERVGLHKVF KLQTSLTCNS MVLFDHVGCL KKYDTVLDIL RDFFELRLKY YGLRKEWLLG MLGAESAKLN NQARFILEKI DGKIIIENKP KKELIKVLIQ RGYDSDPVKA WKEAQQKVPD EEENEESDNE KETEKSDSVT DSGPTFNYLL DMPLWYLTKE KKDELCRLRN EKEQELDTLK RKSPSDLWKE DLATFIEELE AVEAKEKQDE QVGLPGKGGK AKGKKTQMAE VLPSPRGQRV IPRITIEMKA EAEKKNKKKI KNENTEGSPQ EDGVELEGLK QRLEKKQKRE PGTKTKKQTT LAFKPIKKGK KRNPWSDSES DRSSDESNFD VPPRETEPRR AATKTKFTMD LDSDEDFSDF DEKTDDEDFV PSDASPPKTK TSPKLSNKEL KPQKSVVSDL EADDVKGSVP LSSSPPATHF PDETEITNPV PKKNVTVKKT AAKSQSSTST TGAKKRAAPK GTKRDPALNS GVSQKPDPAK TKNRRKRKPS TSDDSDSNFE KIVSKAVTSK KSKGESDDFH MDFDSAVAPR AKSVRAKKPI KYLEESDEDD LF |
Modification Site Information
| Site Position | 96 |
|---|---|
| MS/MS spectra | 24 [show] |
| Best localized sequence | K.IFDEILVNAADNK#QR@.D |
| Matching Proteins |
|
| Site Position | 123 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.VTIDPENNLISIWNNGK#GIPVVEHK.V |
| Matching Proteins |
|
| Site Position | 131 |
|---|---|
| MS/MS spectra | 25 [show] |
| Best localized sequence | K.GIPVVEHK#VEK.V |
| Matching Proteins |
|
| Site Position | 156 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.M*YVPALIFGQLLTSSNYDDDEK#K.V |
| Matching Proteins |
|
| Site Position | 278 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.DK#LDETGNSLK.V |
| Matching Proteins |
|
| Site Position | 580 |
|---|---|
| MS/MS spectra | 77 [show] |
| Best localized sequence | R.EASHK#QIMENAEINNIIK.I |
| Matching Proteins |
|
| Site Position | 601 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.K#NYEDEDSLKTLR.Y |
| Matching Proteins |
|
| Site Position | 610 |
|---|---|
| MS/MS spectra | 17 [show] |
| Best localized sequence | K.NYEDEDSLK#TLR.Y |
| Matching Proteins |
|
| Site Position | 616 |
|---|---|
| MS/MS spectra | 12 [show] |
| Best localized sequence | R.YGK#IMIMTDQDQDGSHIK.G |
| Matching Proteins |
|
| Site Position | 660 |
|---|---|
| MS/MS spectra | 30 [show] |
| Best localized sequence | R.FLEEFITPIVK#VSK.N |
| Matching Proteins |
|
| Site Position | 665 |
|---|---|
| MS/MS spectra | 18 [show] |
| Best localized sequence | K.NK#QEMAFYSLPEFEEWK.S |
| Matching Proteins |
|
| Site Position | 703 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | K.GLGTSTSK#EAK.E |
| Matching Proteins |
|
| Site Position | 720 |
|---|---|
| MS/MS spectra | 9 [show] |
| Best localized sequence | R.IQFK#YSGPEDDAAISLAFSK.K |
| Matching Proteins |
|
| Site Position | 736 |
|---|---|
| MS/MS spectra | 54 [show] |
| Best localized sequence | K.YSGPEDDAAISLAFSK#K.Q |
| Matching Proteins |
|
| Site Position | 743 |
|---|---|
| MS/MS spectra | 76 [show] |
| Best localized sequence | R.K#EWLTNFMEDR.R |
| Matching Proteins |
|
| Site Position | 757 |
|---|---|
| MS/MS spectra | 18 [show] |
| Best localized sequence | R.K#LLGLPEDYLYGQTTTYLTYNDFINK.E |
| Matching Proteins |
|
| Site Position | 974 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.LMDGEEPLPMLPSYK#NFK.G |
| Matching Proteins |
|
| Site Position | 1017 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | R.TWTQTYK#EQVLEPMLNGTEK.T |
| Matching Proteins |
|
| Site Position | 1030 |
|---|---|
| MS/MS spectra | 115 [show] |
| Best localized sequence | K.EQVLEPMLNGTEK#TPPLITDYR.E |
| Matching Proteins |
|
| Site Position | 1143 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | K.IDGK#IIIENKPK.K |
| Matching Proteins |
|
| Site Position | 1240 |
|---|---|
| MS/MS spectra | 10 [show] |
| Best localized sequence | K.EQELDTLK#R@.K |
| Matching Proteins |
|
| Site Position | 1277 |
|---|---|
| MS/MS spectra | 9 [show] |
| Best localized sequence | K.QDEQVGLPGK#GGK.A |
| Matching Proteins |
|
| Site Position | 1285 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | K.K#TQMAEVLPSPR.G |
| Matching Proteins |
|
| Site Position | 1340 |
|---|---|
| MS/MS spectra | 131 [show] |
| Best localized sequence | K.NENTEGSPQEDGVELEGLK#QR.L |
| Matching Proteins |
|