IPI:IPI00478232.3
Protein Information
| Protein | IPI:IPI00478232.3 |
|---|---|
| Gene Symbol | TOP2A |
| Protein Description | Isoform 1 of DNA topoisomerase 2-alpha |
| Sequence Length | 1568 |
| Mwt | 178770.172 Da |
| Sequence | MEVSPLQPVN ENMQVNKIKK NEDAKKRLSV ERIYQKKTQL EHILLRPDTY IGSVELVTQQ MWVYDEDVGI NYREVTFVPG LYKIFDEILV NAADNKQRDP KMSCIRVTID PENNLISIWN NGKGIPVVEH KVEKMYVPAL IFGQLLTSSN YDDDEKKVTG GRNGYGAKLC NIFSTKFTVE TASREYKKMF KQAITWMDNM GRAGEMELKP FNGEDYTCIT FQPDLSKFKM QSLDKDIVAL MVRRAYDIAG STKDVKVFLN GNKLPVKGFR SYVDMYLKDK LDETGNSLKV IHEQVNHRWE VCLTMSEKGF QQISFVNSIA TSKVILFLNY MIYLYIYVFL LFLIYKVDLN IGLAYFTGGR HVDYVADQIV TKLVDVVKKK NKGGVAVKAH QVKNHMWIFV NALIENPTFD SQTKENMTLQ PKSFGSTCQL SEKFIKAAIG CGIVESILNW VKFKAQVQLN KKCSAVKHNR IKGIPKLDDA NDAGGRNSTE CTLILTEGDS AKTLAVSGLG VVGRDKYGVF PLRGKILNVR EASHKQIMEN AEINNIIKIV GLQYKKNYED EDSLKTLRYG KIMIMTDQDQ DGSHIKGLLI NFIHHNWPSL LRHRFLEEFI TPIVKVSKNK QEMAFYSLPE FEEWKSSTPN HKKWKVKYYK GLGTSTSKEA KEYFADMKRH RIQFKYSGPE DDAAISLAFS KKQIDDRKEW LTNFMEDRRQ RKLLGLPEDY LYGQTTTYLT YNDFINKELI LFSNSDNERS IPSMVDGLKP GQRKVLFTCF KRNDKREVKV AQLAGSVAEM SSYHHGEMSL MMTIINLAQN FVGSNNLNLL QPIGQFGTRL HGGKDSASPR YIFTMLSSLA RLLFPPKDDH TLKFLYDDNQ RVEPEWYIPI IPMVLINGAE GIGTGWSCKI PNFDVREIVN NIRRLMDGEE PLPMLPSYKN FKGTIEELAP NQYVISGEVA ILNSTTIEIS ELPVRTWTQT YKEQVLEPML NGTEKTPPLI TDYREYHTDT TVKFVVKMTE EKLAEAERVG LHKVFKLQTS LTCNSMVLFD HVGCLKKYDT VLDILRDFFE LRLKYYGLRK EWLLGMLGAE SAKLNNQARF ILEKIDGKII IENKPKKELI KVLIQRGYDS DPVKAWKEAQ QKVPDEEENE ESDNEKETEK SDSVTDSGPT FNYLLDMPLW YLTKEKKDEL CRLRNEKEQE LDTLKRKSPS DLWKEDLATF IEELEAVEAK EKQDEQVGLP GKGGKAKGKK TQMAEVLPSP RGQRVIPRIT IEMKAEAEKK NKKKIKNENT EGSPQEDGVE LEGLKQRLEK KQKREPGTKT KKQTTLAFKP IKKGKKRNPW SDSESDRSSD ESNFDVPPRE TEPRRAATKT KFTMDLDSDE DFSDFDEKTD DEDFVPSDAS PPKTKTSPKQ NCNKELKPQK SVVSDLEADD VKGSVPLSSS PPATHFPDET EITNPVPKKN VTVKKTAAKS QSSTSTTGAK KRAAPKGTKR DPALNSGVSQ KPDPAKTKNR RKRKPSTSDD SDSNFEKIVS KAVTSKKSKG ESDDFHMDFD SAVAPRAKSV RAKKPIKYLE ESDEDDLF |
Modification Site Information
| Site Position | 96 |
|---|---|
| MS/MS spectra | 24 [show] |
| Best localized sequence | K.IFDEILVNAADNK#QR@.D |
| Matching Proteins |
|
| Site Position | 123 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.VTIDPENNLISIWNNGK#GIPVVEHK.V |
| Matching Proteins |
|
| Site Position | 131 |
|---|---|
| MS/MS spectra | 25 [show] |
| Best localized sequence | K.GIPVVEHK#VEK.V |
| Matching Proteins |
|
| Site Position | 156 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.M*YVPALIFGQLLTSSNYDDDEK#K.V |
| Matching Proteins |
|
| Site Position | 280 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.DK#LDETGNSLK.V |
| Matching Proteins |
|
| Site Position | 535 |
|---|---|
| MS/MS spectra | 77 [show] |
| Best localized sequence | R.EASHK#QIMENAEINNIIK.I |
| Matching Proteins |
|
| Site Position | 556 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.K#NYEDEDSLKTLR.Y |
| Matching Proteins |
|
| Site Position | 565 |
|---|---|
| MS/MS spectra | 17 [show] |
| Best localized sequence | K.NYEDEDSLK#TLR.Y |
| Matching Proteins |
|
| Site Position | 571 |
|---|---|
| MS/MS spectra | 12 [show] |
| Best localized sequence | R.YGK#IMIMTDQDQDGSHIK.G |
| Matching Proteins |
|
| Site Position | 615 |
|---|---|
| MS/MS spectra | 30 [show] |
| Best localized sequence | R.FLEEFITPIVK#VSK.N |
| Matching Proteins |
|
| Site Position | 620 |
|---|---|
| MS/MS spectra | 18 [show] |
| Best localized sequence | K.NK#QEMAFYSLPEFEEWK.S |
| Matching Proteins |
|
| Site Position | 658 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | K.GLGTSTSK#EAK.E |
| Matching Proteins |
|
| Site Position | 675 |
|---|---|
| MS/MS spectra | 9 [show] |
| Best localized sequence | R.IQFK#YSGPEDDAAISLAFSK.K |
| Matching Proteins |
|
| Site Position | 691 |
|---|---|
| MS/MS spectra | 54 [show] |
| Best localized sequence | K.YSGPEDDAAISLAFSK#K.Q |
| Matching Proteins |
|
| Site Position | 698 |
|---|---|
| MS/MS spectra | 76 [show] |
| Best localized sequence | R.K#EWLTNFMEDR.R |
| Matching Proteins |
|
| Site Position | 712 |
|---|---|
| MS/MS spectra | 18 [show] |
| Best localized sequence | R.K#LLGLPEDYLYGQTTTYLTYNDFINK.E |
| Matching Proteins |
|
| Site Position | 929 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.LMDGEEPLPMLPSYK#NFK.G |
| Matching Proteins |
|
| Site Position | 972 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | R.TWTQTYK#EQVLEPMLNGTEK.T |
| Matching Proteins |
|
| Site Position | 985 |
|---|---|
| MS/MS spectra | 115 [show] |
| Best localized sequence | K.EQVLEPMLNGTEK#TPPLITDYR.E |
| Matching Proteins |
|
| Site Position | 1098 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | K.IDGK#IIIENKPK.K |
| Matching Proteins |
|
| Site Position | 1195 |
|---|---|
| MS/MS spectra | 10 [show] |
| Best localized sequence | K.EQELDTLK#R@.K |
| Matching Proteins |
|
| Site Position | 1232 |
|---|---|
| MS/MS spectra | 9 [show] |
| Best localized sequence | K.QDEQVGLPGK#GGK.A |
| Matching Proteins |
|
| Site Position | 1240 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | K.K#TQMAEVLPSPR.G |
| Matching Proteins |
|
| Site Position | 1295 |
|---|---|
| MS/MS spectra | 131 [show] |
| Best localized sequence | K.NENTEGSPQEDGVELEGLK#QR.L |
| Matching Proteins |
|