IPI:IPI00179298.5
Protein Information
| Protein | IPI:IPI00179298.5 |
|---|---|
| Gene Symbol | HUWE1 |
| Protein Description | 482 kDa protein |
| Sequence Length | 4376 |
| Mwt | 481845.792 Da |
| Sequence | MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT TLLASSDMQV VLAVLNLLYV FSKRSNYITR LGSDKRTPLL TRLQHLAESW GGKENGFGLA ECCRDLHMMK YPPSATTLHF EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM ESLTKMYSIP KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT GTASYHGFLP VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG EALVSCGMME ALLKVIKFLG DEQDQITFVT RAVRVVDLIT NLDMAAFQSH SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ RPNTTQEGEE METDMDGVQC IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL KHIISNAEYY GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD PLGDTASNLG SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ KPSIQKADGT ATAPPPRSNH AAEEASSEDE EEEEVQAMQS FNSTQQNETE PNQQVVGTEE RIPIPLMDYI LNVMKFVESI LSNNTTDDHC QEFVNQKGLL PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV LQEGLLQLDS ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV LLSLCTPNSL PSGCEFGQAD MQKLVPKDEK AGTTQGGKRS DGEQDGAAGS MDASTQGLLE GIGLDGDTLA PMETDEPTAS DSKGKSKITP AMAARIKQIK PLLSASSRLG RALAELFGLL VKLCVGSPVR QRRSHHAAST TTAPTPAARS TASALTKLLT KGLSWQPPPY TPTPRFRLTF FICSVGFTSP MLFDERKYPY HLMLQKFLCS GGHNALFETF NWALSMGGKV PVSEGLEHSD LPDGTGEFLD AWLMLVEKMV NPTTVLESPH SLPAKLPGGV QNFPQFSALR FLVVTQKAAF TCIKNLWNRK PLKVYGGRMA ESMLAILCHI LRGEPVIRER LSKEKEGSRG EEDTGQEEGG SRREPQVNQQ QLQQLMDMGF TREHAMEALL NTSTMEQATE YLLTHPPPIM GGVVRDLSMS EEDQMMRAIA MSLGQDIPMD QRAESPEEVA CRKEEEERKA REKQEEEEAK CLEKFQDADP LEQDELHTFT DTMLPGCFHL LDELPDTVYR VCDLIMTAIK RNGADYRDMI LKQVVNQVWE AADVLIKAAL PLTTSDTKTV SEWISQMATL PQASNLATRI LLLTLLFEEL KLPCAWVVES SGILNVLIKL LEVVQPCLQA AKEQKEVQTP KWITPVLLLI DFYEKTAISS KRRAQMTKYL QSNSNNWRWF DDRSGRWCSY SASNNSTIDS AWKSGETSVR FTAGRRRYTV QFTTMVQVNE ETGNRRPVML TLLRVPRLNK NSKNSNGQEL EKTLEESKEM DIKRKENKGN DTPLALESTN TEKETSLEET KIGEILIQGL TEDMVTVLIR ACVSMLGVPV DPDTLHATLR LCLRLTRDHK YAMMFAELKS TRMILNLTQS SGFNGFTPLV TLLLRHIIED PCTLRHTMEK VVRSAATSGA GSTTSGVVSG SLGSREINYI LRVLGPAACR NPDIFTEVAN CCIRIALPAP RGSGTASDDE FENLRIKGPN AVQLVKTTPL KPSPLPVIPD TIKEVIYDML NALAAYHAPE EADKSDPKPG VMTQEVGQLL QDMGDDVYQQ YRSLTRQSSD FDTQSGFSIN SQVFAADGAS TETSASGTSQ GEASTPEESR DGKKDKEGDR ASEEGKQKGK GSKPLMPTST ILRLLAELVR SYVGIATLIA NYSYTVGQSE LIKEDCSVLA FVLDHLLPHT QNAEDKDTPA LARLFLASLA AAGSGTDAQV ALVNEVKAAL GRALAMAEST EKHARLQAVM CIISTIMESC PSTSSFYSSA TAKTQHNGMN NIIRLFLKKG LVNDLARVPH SLDLSSPNMA NTVNAALKPL ETLSRIVNQP SSLFGSKSAS SKNKSEQDAQ GASQDSSSNQ QDPGEPGEAE VQEEDHDVTQ TEVADGDIMD GEAETDSVVI AGQPEVLSSQ EMQVENELED LIDELLERDG GSGNSTIIVS RSGEDESQED VLMDEAPSNL SQASTLQANR EDSMNILDPE DEEEHTQEED SSGSNEDEDD SQDEEEEEEE DEEDDQEDDE GEEGDEDDDD DGSEMELDED YPDMNASPLV RFERFDREDD LIIEFDNMFS SATDIPPSPG NIPTTHPLMV RHADHSSLTL GSGSSTTRLT QGIGRSQRTL RQLTANTGHT IHVHYPGNRQ PNPPLILQRL LGPSAAADIL QLSSSLPLQS RGRARLLVGN DDVHIIARSD DELLDDFFHD QSTATSQAGT LSSIPTALTR WTEECKVLDA ESMHDCVSVV KVSIVNHLEF LRDEELEERR EKRRKQLAEE ETKITDKGKE DKENRDQSAQ CTASKSNDST EQNLSEKDGT PMPDSYPTTP SSTDAATSES KETLGTLQSS QQQPTLPTPP ALGEVPQELQ SPAGEGGSST QLLMPVEPEE LGPTRPSGEA ETTQMELSPA PTITSLSPER AEDSDALTAV SSQLEGSPMD TSSLASCTLE EAVGDTSAAG SSEQPRAGSS TPGDAPPAVA EVQGRSDGSG ESAQPPEDSS PPASSESSST RDSAVAISGA DSRGILEEPL PSTSSEEEDP LAGISLPEGV DPSFLAALPD DIRREVLQNQ LGIRPPTRTA PSTNSSAPAV VGNPGVTEVS PEFLAALPPA IQEEVLAQQR AEQQRRELAQ NASSDTPMDP VTFIQTLPSD LRRSVLEDME DSVLAVMPPD IAAEAQALRR EQEARQRQLM HERLFGHSST SALSAILRSP AFTSRLSGNR GVQYTRLAVQ RGGTFQMGGS SSHNRPSGSN VDTLLRLRGR LLLDHEALSC LLVLLFVDEP KLNTSRLHRV LRNLCYHAQT RHWVIRSLLS ILQRSSESEL CIETPKLTTS EEKGKKSSKS CGSSSHENRP LDLLHKMESK SSNQLSWLSV SMDAALGCRT NIFQIQRSGG RKHTEKHASG GSTVHIHPQA APVVCRHVLD TLIQLAKVFP SHFTQQRTKE TNCESDRERG NKACSPCSSQ SSSSGICTDF WDLLVKLDNM NVSRKGKNSV KSVPVSAGGE GETSPYSLEA SPLGQLMNML SHPVIRRSSL LTEKLLRLLS LISIALPENK VSEAQANSGS GASSTTTATS TTSTTTTTAA STTPTPPTAP TPVTSAPALV AATAISTIVV AASTTVTTPT TATTTVSISP TTKGSKSPAK VSDGGSSSTD FKMVSSGLTE NQLQLSVEVL TSHSCSEEGL EDAANVLLQL SRGDSGTRDT VLKLLLNGAR HLGYTLCKQI GTLLAELREY NLEQQRRAQC ETLSPDGLPE EQPQTTKLKG KMQSRFDMAE NVVIVASQKR PLGGRELQLP SMSMLTSKTS TQKFFLRVLQ VIIQLRDDTR RANKKAKQTG RLGSSGLGSA SSIQAAVRQL EAEADAIIQM VREGQRARRQ QQAATSESSQ SEASVRREES PMDVDQPSPS AQDTQSIASD GTPQGEKEKE ERPPELPLLS EQLSLDELWD MLGECLKELE ESHDQHAVLV LQPAVEAFFL VHATERESKP PVRDTRESQL AHIKDEPPPL SPAPLTPATP SSLDPFFSRE PSSMHISSSL PPDTQKFLRF AETHRTVLNQ ILRQSTTHLA DGPFAVLVDY IRVLDFDVKR KYFRQELERL DEGLRKEDMA VHVRRDHVFE DSYRELHRKS PEEMKNRLYI VFEGEEGQDA GGLLREWYMI ISREMFNPMY ALFRTSPGDR VTYTINPSSH CNPNHLSYFK FVGRIVAKAV YDNRLLECYF TRSFYKHILG KSVRYTDMES EDYHFYQGLV YLLENDVSTL GYDLTFSTEV QEFGVCEVRD LKPNGANILV TEENKKEYVH LVCQMRMTGA IRKQLAAFLE GFYEIIPKRL ISIFTEQELE LLISGLPTID IDDLKSNTEY HKYQSNSIQI QWFWRALRSF DQADRAKFLQ FVTGTSKVPL QGFAALEGMN GIQKFQIHRD DRSTDRLPSA HTCFNQLDLP AYESFEKLRH MLLLAIQECS EGFGLA |
Modification Site Information
| Site Position | 674 |
|---|---|
| MS/MS spectra | 20 [show] |
| Best localized sequence | R.HQPTLK#TDATTAIIK.L |
| Matching Proteins |
|
| Site Position | 1107 |
|---|---|
| MS/MS spectra | 14 [show] |
| Best localized sequence | R.STASALTK#LLTK.G |
| Matching Proteins |
|
| Site Position | 1111 |
|---|---|
| MS/MS spectra | 18 [show] |
| Best localized sequence | K.LLTK#GLSWQPPPYTPTPR.F |
| Matching Proteins |
|
| Site Position | 1225 |
|---|---|
| MS/MS spectra | 5 [show] |
| Best localized sequence | K.MVNPTTVLESPHSLPAK#LPGGVQNFPQFSALR.F |
| Matching Proteins |
|
| Site Position | 1247 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.FLVVTQK#AAFTCIK.N |
| Matching Proteins |
|
| Site Position | 1295 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.EK#EGSRGEEDTGQEEGGSR.R |
| Matching Proteins |
|
| Site Position | 1608 |
|---|---|
| MS/MS spectra | 8 [show] |
| Best localized sequence | R.AQMTK#YLQSNSNNWR@.W |
| Matching Proteins |
|
| Site Position | 1693 |
|---|---|
| MS/MS spectra | 6 [show] |
| Best localized sequence | K.NSK#NSNGQELEK.T |
| Matching Proteins |
|
| Site Position | 1702 |
|---|---|
| MS/MS spectra | 9 [show] |
| Best localized sequence | K.NSNGQELEK#TLEESK.E |
| Matching Proteins |
|
| Site Position | 1708 |
|---|---|
| MS/MS spectra | 10 [show] |
| Best localized sequence | K.TLEESK#EMDIK.R |
| Matching Proteins |
|
| Site Position | 1718 |
|---|---|
| MS/MS spectra | 16 [show] |
| Best localized sequence | K.ENK#GNDTPLALESTNTEK.E |
| Matching Proteins |
|
| Site Position | 1733 |
|---|---|
| MS/MS spectra | 128 [show] |
| Best localized sequence | K.GNDTPLALESTNTEK#ETSLEETK.I |
| Matching Proteins |
|
| Site Position | 1799 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.YAMMFAELK#STR@.M |
| Matching Proteins |
|
| Site Position | 1840 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.HTMEK#VVR.S |
| Matching Proteins |
|
| Site Position | 1917 |
|---|---|
| MS/MS spectra | 41 [show] |
| Best localized sequence | R.IK#GPNAVQLVK.T |
| Matching Proteins |
|
| Site Position | 1926 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | K.GPNAVQLVK#TTPLKPSPLPVIPDTIK.E |
| Matching Proteins |
|
| Site Position | 1931 |
|---|---|
| MS/MS spectra | 112 [show] |
| Best localized sequence | K.TTPLK#PSPLPVIPDTIK.E |
| Matching Proteins |
|
| Site Position | 2218 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.LFLK#K#GLVNDLAR@.V |
| Matching Proteins |
|
| Site Position | 2219 |
|---|---|
| MS/MS spectra | 3 [show] |
| Best localized sequence | R.LFLK#K#GLVNDLAR@.V |
| Matching Proteins |
|
| Site Position | 2248 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | R.VPHSLDLSSPNMANTVNAALK#PLETLSR.I |
| Matching Proteins |
|
| Site Position | 2267 |
|---|---|
| MS/MS spectra | 34 [show] |
| Best localized sequence | R.IVNQPSSLFGSK#SASSK.N |
| Matching Proteins |
|
| Site Position | 2695 |
|---|---|
| MS/MS spectra | 21 [show] |
| Best localized sequence | R.K#QLAEEETK.I |
| Matching Proteins |
|
| Site Position | 2703 |
|---|---|
| MS/MS spectra | 16 [show] |
| Best localized sequence | K.QLAEEETK#ITDK.G |
| Matching Proteins |
|
| Site Position | 3246 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.SSESELCIETPK#LTTSEEK.G |
| Matching Proteins |
|
| Site Position | 3347 |
|---|---|
| MS/MS spectra | 95 [show] |
| Best localized sequence | R.HVLDTLIQLAK#VFPSHFTQQR.T |
| Matching Proteins |
|
| Site Position | 3454 |
|---|---|
| MS/MS spectra | 60 [show] |
| Best localized sequence | R.SSLLTEK#LLR@.L |
| Matching Proteins |
|
| Site Position | 3560 |
|---|---|
| MS/MS spectra | 104 [show] |
| Best localized sequence | K.SPAK#VSDGGSSSTDFK.M |
| Matching Proteins |
|
| Site Position | 3623 |
|---|---|
| MS/MS spectra | 8 [show] |
| Best localized sequence | R.DTVLK#LLLNGAR.H |
| Matching Proteins |
|
| Site Position | 3638 |
|---|---|
| MS/MS spectra | 4 [show] |
| Best localized sequence | R.HLGYTLCK#QIGTLLAELR@.E |
| Matching Proteins |
|
| Site Position | 3699 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.FDMAENVVIVASQK#RPLGGR.E |
| Matching Proteins |
|
| Site Position | 3837 |
|---|---|
| MS/MS spectra | 4 [show] |
| Best localized sequence | R.REESPMDVDQPSPSAQDTQSIASDGTPQGEK#EK.E |
| Matching Proteins |
|
| Site Position | 3914 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | R.ESQLAHIK#DEPPPLSPAPLTPATPSSLDPFFSR.E |
| Matching Proteins |
|
| Site Position | 4118 |
|---|---|
| MS/MS spectra | 11 [show] |
| Best localized sequence | R.IVAK#AVYDNR.L |
| Matching Proteins |
|
| Site Position | 4192 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.DLK#PNGANILVTEENKK.E |
| Matching Proteins |
|
| Site Position | 4297 |
|---|---|
| MS/MS spectra | 3 [show] |
| Best localized sequence | R.AK#FLQFVTGTSK.V |
| Matching Proteins |
|