IPI:IPI00445401.2
Protein Information
| Protein | IPI:IPI00445401.2 |
|---|---|
| Gene Symbol | HUWE1 |
| Protein Description | Isoform 2 of E3 ubiquitin-protein ligase HUWE1 |
| Sequence Length | 4358 |
| Mwt | 479896.778 Da |
| Sequence | MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT TLLASSDMQV VLAVLNLLYV FSKRSNYITR LGSDKRTPLL TRLQHLAESW GGKENGFGLA ECCRDLHMMK YPPSATTLHF EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM ESLTKMYSIP KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT GTASYHGFLP VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG EALVSCGMME ALLKVIKFLG DEQDQITFVT RAVRVVDLIT NLDMAAFQSH SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ RPNTTQEGEE METDMDGVQC IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL KHIISNAEYY GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD PLGDTASNLG SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ KPSIQKADGT ATAPPPRSNH AAEEASSEDE EEEEVQAMQS FNSTQQNETE PNQQVVGTEE RIPIPLMDYI LNVMKFVESI LSNNTTDDHC QEFVNQKGLL PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV LQEGLLQLDS ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV LLSLCTPNSL PSGCEFGQAD MQKLVPKDEK AGTTQGGKRS DGEQDGAAGS MDASTQGLLE GIGLDGDTLA PMETDEPTAS DSKGKSKITP AMAARIKQIK PLLSASSRLG RALAELFGLL VKLCVGSPVR QRRSHHAAST TTAPTPAARS TASALTKLLT KGLSWQPPPY TPTPRFRLTF FICSVGFTSP MLFDERKYPY HLMLQKFLCS GGHNALFETF NWALSMGGKV PVSEGLEHSD LPDGTGEFLD AWLMLVEKMV NPTTVLESPH SLPAKLPGGV QNFPQFSALR FLVVTQKAAF TCIKNLWNRK PLKVYGGRMA ESMLAILCHI LRGEPVIRER LSKEKEGSRG EEDTGQEEGG SRREPQVNQQ QLQQLMDMGF TREHAMEALL NTSTMEQATE YLLTHPPPIM GGVVRDLSMS EEDQMMRAIA MSLGQDIPMD QRAESPEEVA CRKEEEERKA REKQEEEEAK CLEKFQDADP LEQDELHTFT DTMLPGCFHL LDELPDTVYR VCDLIMTAIK RNGADYRDMI LKQVVNQVWE AADVLIKAAL PLTTSDTKTV SEWISQMATL PQASNLATRI LLLTLLFEEL KLPCAWVVES SGILNVLIKL LEVVQPCLQA AKEQKEVQTP KWITPVLLLI DFYEKTAISS KRRAQMTKYL QSNSNNWRWF DDRSGRWCSY SASNNSTIDS AWKSGETSVR FTAGRRRYTV QFTTMVQVNE ETGNRRPVML TLLRVPRLNK NSKNSNGQEL EKTLEESKEM DIKRKENKGN DTPLALESTN TEKETSLEET KIGEILIQGL TEDMVTVLIR ACVSMLGVPV DPDTLHATLR LCLRLTRDHK YAMMFAELKS TRMILNLTQS SGFNGFTPLV TLLLRHIIED PCTLRHTMEK VVRSAATSGA GSTTSGVVSG SLGSREINYI LRVLGPAACR NPDIFTEVAN CCIRIALPAP RGSGTASDDE FENLRIKGPN AVQLVKTTPL KPSPLPVIPD TIKEVIYDML NALAAYHAPE EADKSDPKPG VMTQEVGQLL QDMGDDVYQQ YRSLTRQSSD FDTQSGFSIN SQVFAADGAS TETSASGTSQ GEASTPEESR DGKKDKEGDR ASEEGKQKGK GSKPLMPTST ILRLLAELVR SYVGIATLIA NYSYTVGQSE LIKEDCSVLA FVLDHLLPHT QNAEDKDTPA LARLFLASLA AAGSGTDAQV ALVNEVKAAL GRALAMAEST EKHARLQAVM CIISTIMESC PSTSSFYSSA TAKTQHNGMN NIIRLFLKKG LVNDLARVPH SLDLSSPNMA NTVNAALKPL ETLSRIVNQP SSLFGSKSAS SKNKSEQDAQ GASQDSSSNQ QDPGEPGEAE VQEEDHDVTQ TEVADGDIMD GEAETDSVVI AGQPEVLSSQ EMQVENELED LIDELLERDG GSGNSTIIVS RSGEDESQED VLMDEAPSNL SQASTLQANR EDSMNILDPE DEEEHTQEED SSGSNEDEDD SQDEEEEEEE DEEDDQEDDE GEEGDEDDDD DGSEMELDED YPDMNASPLV RFERFDREDD LIIEFDNMFS SATDIPPSPG NIPTTHPLMV RHADHSSLTL GSGSSTTRLT QGIGRSQRTL RQLTANTGHT IHVHYPGNRQ PNPPLILQRL LGPSAAADIL QLSSSLPLQS RGRARLLVGN DDVHIIARSD DELLDDFFHD QSTATSQAGT LSSIPTALTR WTEECKVLDA ESMHDCVSVV KVSIVNHLEF LRDEELEERR EKRRKQLAEE ETKITDKGKE DKENRDQSAQ CTASKSNDST EQNLSDGTPM PDSYPTTPSS TDAATSESKE TLGTLQSSQQ QPTLPTPPAL GEVPQELQSP AGEGGSSTQL LMPVEPEELG PTRPSGEAET TQMELSPAPT ITSLSPERAE DSDALTAVSS QLEGSPMDTS SLASCTLEEA VGDTSAAGSS EQPRAGSSTP GDAPPAVAEV QGRSDGSGES AQPPEDSSPP ASSESSSTRD SAVAISGADS RGILEEPLPS TSSEEEDPLA GISLPEGVDP SFLAALPDDI RREVLQNQLG IRPPTRTAPS TNSSAPAVVG NPGVTEVLAQ QRAEQQRREL AQNASSDTPM DPVTFIQTLP SDLRRSVLED MEDSVLAVMP PDIAAEAQAL RREQEARQRQ LMHERLFGHS STSALSAILR SPAFTSRLSG NRGVQYTRLA VQRGGTFQMG GSSSHNRPSG SNVDTLLRLR GRLLLDHEAL SCLLVLLFVD EPKLNTSRLH RVLRNLCYHA QTRHWVIRSL LSILQRSSES ELCIETPKLT TSEEKGKKSS KSCGSSSHEN RPLDLLHKME SKSSNQLSWL SVSMDAALGC RTNIFQIQRS GGRKHTEKHA SGGSTVHIHP QAAPVVCRHV LDTLIQLAKV FPSHFTQQRT KETNCESDRE RGNKACSPCS SQSSSSGICT DFWDLLVKLD NMNVSRKGKN SVKSVPVSAG GEGETSPYSL EASPLGQLMN MLSHPVIRRS SLLTEKLLRL LSLISIALPE NKVSEAQANS GSGASSTTTA TSTTSTTTTT AASTTPTPPT APTPVTSAPA LVAATAISTI VVAASTTVTT PTTATTTVSI SPTTKGSKSP AKVSDGGSSS TDFKMVSSGL TENQLQLSVE VLTSHSCSEE GLEDAANVLL QLSRGDSGTR DTVLKLLLNG ARHLGYTLCK QIGTLLAELR EYNLEQQRRA QCETLSPDGL PEEQPQTTKL KGKMQSRFDM AENVVIVASQ KRPLGGRELQ LPSMSMLTSK TSTQKFFLRV LQVIIQLRDD TRRANKKAKQ TGRLGSSGLG SASSIQAAVR QLEAEADAII QMVREGQRAR RQQQAATSES SQSEASVRRE ESPMDVDQPS PSAQDTQSIA SDGTPQGEKE KEERPPELPL LSEQLSLDEL WDMLGECLKE LEESHDQHAV LVLQPAVEAF FLVHATERES KPPVRDTRES QLAHIKDEPP PLSPAPLTPA TPSSLDPFFS REPSSMHISS SLPPDTQKFL RFAETHRTVL NQILRQSTTH LADGPFAVLV DYIRVLDFDV KRKYFRQELE RLDEGLRKED MAVHVRRDHV FEDSYRELHR KSPEEMKNRL YIVFEGEEGQ DAGGLLREWY MIISREMFNP MYALFRTSPG DRVTYTINPS SHCNPNHLSY FKFVGRIVAK AVYDNRLLEC YFTRSFYKHI LGKSVRYTDM ESEDYHFYQG LVYLLENDVS TLGYDLTFST EVQEFGVCEV RDLKPNGANI LVTEENKKEY VHLVCQMRMT GAIRKQLAAF LEGFYEIIPK RLISIFTEQE LELLISGLPT IDIDDLKSNT EYHKYQSNSI QIQWFWRALR SFDQADRAKF LQFVTGTSKV PLQGFAALEG MNGIQKFQIH RDDRSTDRLP SAHTCFNQLD LPAYESFEKL RHMLLLAIQE CSEGFGLA |
Modification Site Information
| Site Position | 674 |
|---|---|
| MS/MS spectra | 20 [show] |
| Best localized sequence | R.HQPTLK#TDATTAIIK.L |
| Matching Proteins |
|
| Site Position | 1107 |
|---|---|
| MS/MS spectra | 14 [show] |
| Best localized sequence | R.STASALTK#LLTK.G |
| Matching Proteins |
|
| Site Position | 1111 |
|---|---|
| MS/MS spectra | 18 [show] |
| Best localized sequence | K.LLTK#GLSWQPPPYTPTPR.F |
| Matching Proteins |
|
| Site Position | 1225 |
|---|---|
| MS/MS spectra | 5 [show] |
| Best localized sequence | K.MVNPTTVLESPHSLPAK#LPGGVQNFPQFSALR.F |
| Matching Proteins |
|
| Site Position | 1247 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.FLVVTQK#AAFTCIK.N |
| Matching Proteins |
|
| Site Position | 1295 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.EK#EGSRGEEDTGQEEGGSR.R |
| Matching Proteins |
|
| Site Position | 1608 |
|---|---|
| MS/MS spectra | 8 [show] |
| Best localized sequence | R.AQMTK#YLQSNSNNWR@.W |
| Matching Proteins |
|
| Site Position | 1693 |
|---|---|
| MS/MS spectra | 6 [show] |
| Best localized sequence | K.NSK#NSNGQELEK.T |
| Matching Proteins |
|
| Site Position | 1702 |
|---|---|
| MS/MS spectra | 9 [show] |
| Best localized sequence | K.NSNGQELEK#TLEESK.E |
| Matching Proteins |
|
| Site Position | 1708 |
|---|---|
| MS/MS spectra | 10 [show] |
| Best localized sequence | K.TLEESK#EMDIK.R |
| Matching Proteins |
|
| Site Position | 1718 |
|---|---|
| MS/MS spectra | 16 [show] |
| Best localized sequence | K.ENK#GNDTPLALESTNTEK.E |
| Matching Proteins |
|
| Site Position | 1733 |
|---|---|
| MS/MS spectra | 128 [show] |
| Best localized sequence | K.GNDTPLALESTNTEK#ETSLEETK.I |
| Matching Proteins |
|
| Site Position | 1799 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.YAMMFAELK#STR@.M |
| Matching Proteins |
|
| Site Position | 1840 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.HTMEK#VVR.S |
| Matching Proteins |
|
| Site Position | 1917 |
|---|---|
| MS/MS spectra | 41 [show] |
| Best localized sequence | R.IK#GPNAVQLVK.T |
| Matching Proteins |
|
| Site Position | 1926 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | K.GPNAVQLVK#TTPLKPSPLPVIPDTIK.E |
| Matching Proteins |
|
| Site Position | 1931 |
|---|---|
| MS/MS spectra | 112 [show] |
| Best localized sequence | K.TTPLK#PSPLPVIPDTIK.E |
| Matching Proteins |
|
| Site Position | 2218 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.LFLK#K#GLVNDLAR@.V |
| Matching Proteins |
|
| Site Position | 2219 |
|---|---|
| MS/MS spectra | 3 [show] |
| Best localized sequence | R.LFLK#K#GLVNDLAR@.V |
| Matching Proteins |
|
| Site Position | 2248 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | R.VPHSLDLSSPNMANTVNAALK#PLETLSR.I |
| Matching Proteins |
|
| Site Position | 2267 |
|---|---|
| MS/MS spectra | 34 [show] |
| Best localized sequence | R.IVNQPSSLFGSK#SASSK.N |
| Matching Proteins |
|
| Site Position | 2695 |
|---|---|
| MS/MS spectra | 21 [show] |
| Best localized sequence | R.K#QLAEEETK.I |
| Matching Proteins |
|
| Site Position | 2703 |
|---|---|
| MS/MS spectra | 16 [show] |
| Best localized sequence | K.QLAEEETK#ITDK.G |
| Matching Proteins |
|
| Site Position | 3228 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.SSESELCIETPK#LTTSEEK.G |
| Matching Proteins |
|
| Site Position | 3329 |
|---|---|
| MS/MS spectra | 95 [show] |
| Best localized sequence | R.HVLDTLIQLAK#VFPSHFTQQR.T |
| Matching Proteins |
|
| Site Position | 3436 |
|---|---|
| MS/MS spectra | 60 [show] |
| Best localized sequence | R.SSLLTEK#LLR@.L |
| Matching Proteins |
|
| Site Position | 3542 |
|---|---|
| MS/MS spectra | 104 [show] |
| Best localized sequence | K.SPAK#VSDGGSSSTDFK.M |
| Matching Proteins |
|
| Site Position | 3605 |
|---|---|
| MS/MS spectra | 8 [show] |
| Best localized sequence | R.DTVLK#LLLNGAR.H |
| Matching Proteins |
|
| Site Position | 3620 |
|---|---|
| MS/MS spectra | 4 [show] |
| Best localized sequence | R.HLGYTLCK#QIGTLLAELR@.E |
| Matching Proteins |
|
| Site Position | 3681 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.FDMAENVVIVASQK#RPLGGR.E |
| Matching Proteins |
|
| Site Position | 3819 |
|---|---|
| MS/MS spectra | 4 [show] |
| Best localized sequence | R.REESPMDVDQPSPSAQDTQSIASDGTPQGEK#EK.E |
| Matching Proteins |
|
| Site Position | 3896 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | R.ESQLAHIK#DEPPPLSPAPLTPATPSSLDPFFSR.E |
| Matching Proteins |
|
| Site Position | 4100 |
|---|---|
| MS/MS spectra | 11 [show] |
| Best localized sequence | R.IVAK#AVYDNR.L |
| Matching Proteins |
|
| Site Position | 4174 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.DLK#PNGANILVTEENKK.E |
| Matching Proteins |
|
| Site Position | 4279 |
|---|---|
| MS/MS spectra | 3 [show] |
| Best localized sequence | R.AK#FLQFVTGTSK.V |
| Matching Proteins |
|