IPI:IPI00643153.1
Protein Information
| Protein | IPI:IPI00643153.1 |
|---|---|
| Gene Symbol | HUWE1 |
| Protein Description | Isoform 3 of E3 ubiquitin-protein ligase HUWE1 |
| Sequence Length | 4365 |
| Mwt | 480716.208 Da |
| Sequence | MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT TLLASSDMQV VLAVLNLLYV FSKRSNYITR LGSDKRTPLL TRLQHLAESW GGKENGFGLA ECCRDLHMMK YPPSATTLHF EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM ESLTKMYSIP KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT GTASYHGFLP VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG EALVSCGMME ALLKVIKFLG DEQDQITFVT RAVRVVDLIT NLDMAAFQSH SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ RPNTTQEGEE METDMDGVQC IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL KHIISNAEYY GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD PLGDTASNLG SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ KPSIQKADGT ATAPPPRSNH AAEEASSEDE EEEEVQAMQS FNSTQQNETE PNQQVVGTEE RIPIPLMDYI LNVMKFVESI LSNNTTDDHC QEFVNQKGLL PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV LQEGLLQLDS ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV LLSLCTPNSL PSGCEFGQAD MQKLVPKDEK ADGEQDGAAG SMDASTQGLL EGIGLDGDTL APMETDEPTA SDSKGKSKIT PAMAARIKQI KPLLSASSRL GRALAELFGL LVKLCVGSPV RQRRSHHAAS TTTAPTPAAR STASALTKLL TKGLSWQPPP YTPTPRFRLT FFICSVGFTS PMLFDERKYP YHLMLQKFLC SGGHNALFET FNWALSMGGK VPVSEGLEHS DLPDGTGEFL DAWLMLVEKM VNPTTVLESP HSLPAKLPGG VQNFPQFSAL RFLVVTQKAA FTCIKNLWNR KPLKVYGGRM AESMLAILCH ILRGEPVIRE RLSKEKEGSR GEEDTGQEEG GSRREPQVNQ QQLQQLMDMG FTREHAMEAL LNTSTMEQAT EYLLTHPPPI MGGVVRDLSM SEEDQMMRAI AMSLGQDIPM DQRAESPEEV ACRKEEEERK AREKQEEEEA KCLEKFQDAD PLEQDELHTF TDTMLPGCFH LLDELPDTVY RVCDLIMTAI KRNGADYRDM ILKQVVNQVW EAADVLIKAA LPLTTSDTKT VSEWISQMAT LPQASNLATR ILLLTLLFEE LKLPCAWVVE SSGILNVLIK LLEVVQPCLQ AAKEQKEVQT PKWITPVLLL IDFYEKTAIS SKRRAQMTKY LQSNSNNWRW FDDRSGRWCS YSASNNSTID SAWKSGETSV RFTAGRRRYT VQFTTMVQVN EETGNRRPVM LTLLRVPRLN KNSKNSNGQE LEKTLEESKE MDIKRKENKG NDTPLALEST NTEKETSLEE TKIGEILIQG LTEDMVTVLI RACVSMLGVP VDPDTLHATL RLCLRLTRDH KYAMMFAELK STRMILNLTQ SSGFNGFTPL VTLLLRHIIE DPCTLRHTME KVVRSAATSG AGSTTSGVVS GSLGSREINY ILRVLGPAAC RNPDIFTEVA NCCIRIALPA PRGSGTASDD EFENLRIKGP NAVQLVKTTP LKPSPLPVIP DTIKEVIYDM LNALAAYHAP EEADKSDPKP GVMTQEVGQL LQDMGDDVYQ QYRSLTRQSS DFDTQSGFSI NSQVFAADGA STETSASGTS QGEASTPEES RDGKKDKEGD RASEEGKQKG KGSKPLMPTS TILRLLAELV RSYVGIATLI ANYSYTVGQS ELIKEDCSVL AFVLDHLLPH TQNAEDKDTP ALARLFLASL AAAGSGTDAQ VALVNEVKAA LGRALAMAES TEKHARLQAV MCIISTIMES CPSTSSFYSS ATAKTQHNGM NNIIRLFLKK GLVNDLARVP HSLDLSSPNM ANTVNAALKP LETLSRIVNQ PSSLFGSKSA SSKNKSEQDA QGASQDSSSN QQDPGEPGEA EVQEEDHDVT QTEVADGDIM DGEAETDSVV IAGQPEVLSS QEMQVENELE DLIDELLERD GGSGNSTIIV SRSGEDESQE DVLMDEAPSN LSQASTLQAN REDSMNILDP EDEEEHTQEE DSSGSNEDED DSQDEEEEEE EDEEDDQEDD EGEEGDEDDD DDGSEMELDE DYPDMNASPL VRFERFDRED DLIIEFDNMF SSATDIPPSP GNIPTTHPLM VRHADHSSLT LGSGSSTTRL TQGIGRSQRT LRQLTANTGH TIHVHYPGNR QPNPPLILQR LLGPSAAADI LQLSSSLPLQ SRGRARLLVG NDDVHIIARS DDELLDDFFH DQSTATSQAG TLSSIPTALT RWTEECKVLD AESMHDCVSV VKVSIVNHLE FLRDEELEER REKRRKQLAE EETKITDKGK EDKENRDQSA QCTASKSNDS TEQNLSDGTP MPDSYPTTPS STDAATSESK ETLGTLQSSQ QQPTLPTPPA LGEVPQELQS PAGEGGSSTQ LLMPVEPEEL GPTRPSGEAE TTQMELSPAP TITSLSPERA EDSDALTAVS SQLEGSPMDT SSLASCTLEE AVGDTSAAGS SEQPRAGSST PGDAPPAVAE VQGRSDGSGE SAQPPEDSSP PASSESSSTR DSAVAISGAD SRGILEEPLP STSSEEEDPL AGISLPEGVD PSFLAALPDD IRREVLQNQL GIRPPTRTAP STNSSAPAVV GNPGVTEVSP EFLAALPPAI QEEVLAQQRA EQQRRELAQN ASSDTPMDPV TFIQTLPSDL RRSVLEDMED SVLAVMPPDI AAEAQALRRE QEARQRQLMH ERLFGHSSTS ALSAILRSPA FTSRLSGNRG VQYTRLAVQR GGTFQMGGSS SHNRPSGSNV DTLLRLRGRL LLDHEALSCL LVLLFVDEPK LNTSRLHRVL RNLCYHAQTR HWVIRSLLSI LQRSSESELC IETPKLTTSE EKGKKSSKSC GSSSHENRPL DLLHKMESKS SNQLSWLSVS MDAALGCRTN IFQIQRSGGR KHTEKHASGG STVHIHPQAA PVVCRHVLDT LIQLAKVFPS HFTQQRTKET NCESDRERGN KACSPCSSQS SSSGICTDFW DLLVKLDNMN VSRKGKNSVK SVPVSAGGEG ETSPYSLEAS PLGQLMNMLS HPVIRRSSLL TEKLLRLLSL ISIALPENKV SEAQANSGSG ASSTTTATST TSTTTTTAAS TTPTPPTAPT PVTSAPALVA ATAISTIVVA ASTTVTTPTT ATTTVSISPT TKGSKSPAKV SDGGSSSTDF KMVSSGLTEN QLQLSVEVLT SHSCSEEGLE DAANVLLQLS RGDSGTRDTV LKLLLNGARH LGYTLCKQIG TLLAELREYN LEQQRRAQCE TLSPDGLPEE QPQTTKLKGK MQSRFDMAEN VVIVASQKRP LGGRELQLPS MSMLTSKTST QKFFLRVLQV IIQLRDDTRR ANKKAKQTGR LGSSGLGSAS SIQAAVRQLE AEADAIIQMV REGQRARRQQ QAATSESSQS EASVRREESP MDVDQPSPSA QDTQSIASDG TPQGEKEKEE RPPELPLLSE QLSLDELWDM LGECLKELEE SHDQHAVLVL QPAVEAFFLV HATERESKPP VRDTRESQLA HIKDEPPPLS PAPLTPATPS SLDPFFSREP SSMHISSSLP PDTQKFLRFA ETHRTVLNQI LRQSTTHLAD GPFAVLVDYI RVLDFDVKRK YFRQELERLD EGLRKEDMAV HVRRDHVFED SYRELHRKSP EEMKNRLYIV FEGEEGQDAG GLLREWYMII SREMFNPMYA LFRTSPGDRV TYTINPSSHC NPNHLSYFKF VGRIVAKAVY DNRLLECYFT RSFYKHILGK SVRYTDMESE DYHFYQGLVY LLENDVSTLG YDLTFSTEVQ EFGVCEVRDL KPNGANILVT EENKKEYVHL VCQMRMTGAI RKQLAAFLEG FYEIIPKRLI SIFTEQELEL LISGLPTIDI DDLKSNTEYH KYQSNSIQIQ WFWRALRSFD QADRAKFLQF VTGTSKVPLQ GFAALEGMNG IQKFQIHRDD RSTDRLPSAH TCFNQLDLPA YESFEKLRHM LLLAIQECSE GFGLA |
Modification Site Information
| Site Position | 674 |
|---|---|
| MS/MS spectra | 20 [show] |
| Best localized sequence | R.HQPTLK#TDATTAIIK.L |
| Matching Proteins |
|
| Site Position | 1098 |
|---|---|
| MS/MS spectra | 14 [show] |
| Best localized sequence | R.STASALTK#LLTK.G |
| Matching Proteins |
|
| Site Position | 1102 |
|---|---|
| MS/MS spectra | 18 [show] |
| Best localized sequence | K.LLTK#GLSWQPPPYTPTPR.F |
| Matching Proteins |
|
| Site Position | 1216 |
|---|---|
| MS/MS spectra | 5 [show] |
| Best localized sequence | K.MVNPTTVLESPHSLPAK#LPGGVQNFPQFSALR.F |
| Matching Proteins |
|
| Site Position | 1238 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.FLVVTQK#AAFTCIK.N |
| Matching Proteins |
|
| Site Position | 1286 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.EK#EGSRGEEDTGQEEGGSR.R |
| Matching Proteins |
|
| Site Position | 1599 |
|---|---|
| MS/MS spectra | 8 [show] |
| Best localized sequence | R.AQMTK#YLQSNSNNWR@.W |
| Matching Proteins |
|
| Site Position | 1684 |
|---|---|
| MS/MS spectra | 6 [show] |
| Best localized sequence | K.NSK#NSNGQELEK.T |
| Matching Proteins |
|
| Site Position | 1693 |
|---|---|
| MS/MS spectra | 9 [show] |
| Best localized sequence | K.NSNGQELEK#TLEESK.E |
| Matching Proteins |
|
| Site Position | 1699 |
|---|---|
| MS/MS spectra | 10 [show] |
| Best localized sequence | K.TLEESK#EMDIK.R |
| Matching Proteins |
|
| Site Position | 1709 |
|---|---|
| MS/MS spectra | 16 [show] |
| Best localized sequence | K.ENK#GNDTPLALESTNTEK.E |
| Matching Proteins |
|
| Site Position | 1724 |
|---|---|
| MS/MS spectra | 128 [show] |
| Best localized sequence | K.GNDTPLALESTNTEK#ETSLEETK.I |
| Matching Proteins |
|
| Site Position | 1790 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.YAMMFAELK#STR@.M |
| Matching Proteins |
|
| Site Position | 1831 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.HTMEK#VVR.S |
| Matching Proteins |
|
| Site Position | 1908 |
|---|---|
| MS/MS spectra | 41 [show] |
| Best localized sequence | R.IK#GPNAVQLVK.T |
| Matching Proteins |
|
| Site Position | 1917 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | K.GPNAVQLVK#TTPLKPSPLPVIPDTIK.E |
| Matching Proteins |
|
| Site Position | 1922 |
|---|---|
| MS/MS spectra | 112 [show] |
| Best localized sequence | K.TTPLK#PSPLPVIPDTIK.E |
| Matching Proteins |
|
| Site Position | 2209 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.LFLK#K#GLVNDLAR@.V |
| Matching Proteins |
|
| Site Position | 2210 |
|---|---|
| MS/MS spectra | 3 [show] |
| Best localized sequence | R.LFLK#K#GLVNDLAR@.V |
| Matching Proteins |
|
| Site Position | 2239 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | R.VPHSLDLSSPNMANTVNAALK#PLETLSR.I |
| Matching Proteins |
|
| Site Position | 2258 |
|---|---|
| MS/MS spectra | 34 [show] |
| Best localized sequence | R.IVNQPSSLFGSK#SASSK.N |
| Matching Proteins |
|
| Site Position | 2686 |
|---|---|
| MS/MS spectra | 21 [show] |
| Best localized sequence | R.K#QLAEEETK.I |
| Matching Proteins |
|
| Site Position | 2694 |
|---|---|
| MS/MS spectra | 16 [show] |
| Best localized sequence | K.QLAEEETK#ITDK.G |
| Matching Proteins |
|
| Site Position | 3235 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.SSESELCIETPK#LTTSEEK.G |
| Matching Proteins |
|
| Site Position | 3336 |
|---|---|
| MS/MS spectra | 95 [show] |
| Best localized sequence | R.HVLDTLIQLAK#VFPSHFTQQR.T |
| Matching Proteins |
|
| Site Position | 3443 |
|---|---|
| MS/MS spectra | 60 [show] |
| Best localized sequence | R.SSLLTEK#LLR@.L |
| Matching Proteins |
|
| Site Position | 3549 |
|---|---|
| MS/MS spectra | 104 [show] |
| Best localized sequence | K.SPAK#VSDGGSSSTDFK.M |
| Matching Proteins |
|
| Site Position | 3612 |
|---|---|
| MS/MS spectra | 8 [show] |
| Best localized sequence | R.DTVLK#LLLNGAR.H |
| Matching Proteins |
|
| Site Position | 3627 |
|---|---|
| MS/MS spectra | 4 [show] |
| Best localized sequence | R.HLGYTLCK#QIGTLLAELR@.E |
| Matching Proteins |
|
| Site Position | 3688 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.FDMAENVVIVASQK#RPLGGR.E |
| Matching Proteins |
|
| Site Position | 3826 |
|---|---|
| MS/MS spectra | 4 [show] |
| Best localized sequence | R.REESPMDVDQPSPSAQDTQSIASDGTPQGEK#EK.E |
| Matching Proteins |
|
| Site Position | 3903 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | R.ESQLAHIK#DEPPPLSPAPLTPATPSSLDPFFSR.E |
| Matching Proteins |
|
| Site Position | 4107 |
|---|---|
| MS/MS spectra | 11 [show] |
| Best localized sequence | R.IVAK#AVYDNR.L |
| Matching Proteins |
|
| Site Position | 4181 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.DLK#PNGANILVTEENKK.E |
| Matching Proteins |
|
| Site Position | 4286 |
|---|---|
| MS/MS spectra | 3 [show] |
| Best localized sequence | R.AK#FLQFVTGTSK.V |
| Matching Proteins |
|