IPI:IPI00746059.2
Protein Information
| Protein | IPI:IPI00746059.2 |
|---|---|
| Gene Symbol | HUWE1 |
| Protein Description | HECT, UBA and WWE domain containing 1 |
| Sequence Length | 3408 |
| Mwt | 374075.589 Da |
| Sequence | XSLPSGCEFG QADMQKLVPK DEKADGEQDG AAGSMDASTQ GLLEGIGLDG DTLAPMETDE PTASDSKGKS KITPAMAARI KQIKPLLSAS SRLGRALAEL FGLLVKLCVG SPVRQRRSHH AASTTTAPTP AARSTASALT KLLTKGLSWQ PPPYTPTPRF RLTFFICSVG FTSPMLFDER KYPYHLMLQK FLCSGGHNAL FETFNWALSM GGKVPVSEGL EHSDLPDGTG EFLDAWLMLV EKMVNPTTVL ESPHSLPAKL PGGVQNFPQF SALRFLVVTQ KAAFTCIKNL WNRKPLKVYG GRMAESMLAI LCHILRGEPV IRERLSKEKE GSRGEEDTGQ EEGGSRREPQ VNQQQLQQLM DMGFTREHAM EALLNTSTME QATEYLLTHP PPIMGGVVRD LSMSEEDQMM RAIAMSLGQD IPMDQRAESP EEVACRKEEE ERKAREKQEE EEAKCLEKFQ DADPLEQDEL HTFTDTMLPG CFHLLDELPD TVYRVCDLIM TAIKRNGADY RDMILKQVVN QVWEAADVLI KAALPLTTSD TKTVSEWISQ MATLPQASNL ATRILLLTLL FEELKLPCAW VVESSGILNV LIKLLEVVQP CLQAAKEQKE VQTPKWITPV LLLIDFYEKT AISSKRRAQM TKYLQSNSNN WRWFDDRSGR WCSYSASNNS TIDSAWKSGE TSVRFTAGRR RYTVQFTTMV QVNEETGNRR PVMLTLLRVP RLNKNSKNSN GQELEKTLEE SKEMDIKRKE NKGNDTPLAL ESTNTEKETS LEETKIGEIL IQGLTEDMVT VLIRACVSML GVPVDPDTLH ATLRLCLRLT RDHKYAMMFA ELKSTRMILN LTQSSGFNGF TPLVTLLLRH IIEDPCTLRH TMEKVVRSAA TSGAGSTTSG VVSGSLGSRE INYILRVLGP AACRNPDIFT EVANCCIRIA LPAPRGSGTA SDDEFENLRI KGPNAVQLVK TTPLKPSPLP VIPDTIKEVI YDMLNALAAY HAPEEADKSD PKPGVMTQEV GQLLQDMGDD VYQQYRSLTR QSSDFDTQSG FSINSQVFAA DGASTETSAS GTSQGEASTP EESRDGKKDK EGDRASEEGK QKGKGSKPLM PTSTILRLLA ELVRSYVGIA TLIANYSYTV GQSELIKEDC SVLAFVLDHL LPHTQNAEDK DTPALARLFL ASLAAAGSGT DAQVALVNEV KAALGRALAM AESTEKHARL QAVMCIISTI MESCPSTSSF YSSATAKTQH NGMNNIIRLF LKKGLVNDLA RVPHSLDLSS PNMANTVNAA LKPLETLSRI VNQPSSLFGS KSASSKNKSE QDAQGASQDS SSNQQDPGEP GEAEVQEEDH DVTQTEVADG DIMDGEAETD SVVIAGQPEV LSSQEMQVEN ELEDLIDELL ERDGGSGNST IIVSRSGEDE SQEDVLMDEA PSNLSQASTL QANREDSMNI LDPEDEEEHT QEEDSSGSNE DEDDSQDEEE EEEEDEEDDQ EDDEGEEGDE DDDDDGSEME LDEDYPDMNA SPLVRFERFD REDDLIIEFD NMFSSATDIP PSPGNIPTTH PLMVRHADHS SLTLGSGSST TRLTQGIGRS QRTLRQLTAN TGHTIHVHYP GNRQPNPPLI LQRLLGPSAA ADILQLSSSL PLQSRGRARL LVGNDDVHII ARSDDELLDD FFHDQSTATS QAGTLSSIPT ALTRWTEECK VLDAESMHDC VSVVKVSIVN HLEFLRDEEL EERREKRRKQ LAEEETKITD KGKEDKENRD QSAQCTASKS NDSTEQNLSD GTPMPDSYPT TPSSTDAATS ESKETLGTLQ SSQQQPTLPT PPALGEVPQE LQSPAGEGGS STQLLMPVEP EELGPTRPSG EAETTQMELS PAPTITSLSP ERAEDSDALT AVSSQLEGSP MDTSSLASCT LEEAVGDTSA AGSSEQPRAG SSTPGDAPPA VAEVQGRSDG SGESAQPPED SSPPASSESS STRDSAVAIS GADSRGILEE PLPSTSSEEE DPLAGISLPE GVDPSFLAAL PDDIRREVLQ NQLGIRPPTR TAPSTNSSAP AVVGNPGVTE VSPEFLAALP PAIQEEVLAQ QRAEQQRREL AQNASSDTPM DPVTFIQTLP SDLRRSVLED MEDSVLAVMP PDIAAEAQAL RREQEARQRQ LMHERLFGHS STSALSAILR SPAFTSRLSG NRGVQYTRLA VQRGGTFQMG GSSSHNRPSG SNVDTLLRLR GRLLLDHEAL SCLLVLLFVD EPKLNTSRLH RVLRNLCYHA QTRHWVIRSL LSILQRSSES ELCIETPKLT TSEEKGKKSS KSCGSSSHEN RPLDLLHKME SKSSNQLSWL SVSMDAALGC RTNIFQIQRS GGRKHTEKHA SGGSTVHIHP QAAPVVCRHV LDTLIQLAKV FPSHFTQQRT KETNCESDRE RGNKACSPCS SQSSSSGICT DFWDLLVKLD NMNVSRKGKN SVKSVPVSAG GEGETSPYSL EASPLGQLMN MLSHPVIRRS SLLTEKLLRL LSLISIALPE NKVSEAQANS GSGASSTTTA TSTTSTTTTT AASTTPTPPT APTPVTSAPA LVAATAISTI VVAASTTVTT PTTATTTVSI SPTTKGSKSP AKVSDGGSSS TDFKMVSSGL TENQLQLSVE VLTSHSCSEE GLEDAANVLL QLSRGDSGTR DTVLKLLLNG ARHLGYTLCK QIGTLLAELR EYNLEQQRRA QCETLSPDGL PEEQPQTTKL KGKMQSRFDM AENVVIVASQ KRPLGGRELQ LPSMSMLTSK TSTQKFFLRV LQVIIQLRDD TRRANKKAKQ TGRLGSSGLG SASSIQAAVR QLEAEADAII QMVREGQRAR RQQQAATSES SQSEASVRRE ESPMDVDQPS PSAQDTQSIA SDGTPQGEKE KEERPPELPL LSEQLSLDEL WDMLGECLKE LEESHDQHAV LVLQPAVEAF FLVHATERES KPPVRDTRES QLAHIKDEPP PLSPAPLTPA TPSSLDPFFS REPSSMHISS SLPPDTQKFL RFAETHRTVL NQILRQSTTH LADGPFAVLV DYIRVLDFDV KRKYFRQELE RLDEGLRKED MAVHVRRDHV FEDSYRELHR KSPEEMKNRL YIVFEGEEGQ DAGGLLREWY MIISREMFNP MYALFRTSPG DRVTYTINPS SHCNPNHLSY FKFVGRIVAK AVYDNRLLEC YFTRSFYKHI LGKSVRYTDM ESEDYHFYQG LVYLLENDVS TLGYDLTFST EVQEFGVCEV RDLKPNGANI LVTEENKKEY VHLVCQMRMT GAIRKQLAAF LEGFYEIIPK RLISIFTEQE LELLISGLPT IDIDDLKSNT EYHKYQSNSI QIQWFWRALR SFDQADRAKF LQFVTGTSKV PLQGFAALEG MNGIQKFQIH RDDRSTDRLP SAHTCFNQLD LPAYESFEKL RHMLLLAIQE CSEGFGLA |
Modification Site Information
| Site Position | 141 |
|---|---|
| MS/MS spectra | 14 [show] |
| Best localized sequence | R.STASALTK#LLTK.G |
| Matching Proteins |
|
| Site Position | 145 |
|---|---|
| MS/MS spectra | 18 [show] |
| Best localized sequence | K.LLTK#GLSWQPPPYTPTPR.F |
| Matching Proteins |
|
| Site Position | 259 |
|---|---|
| MS/MS spectra | 5 [show] |
| Best localized sequence | K.MVNPTTVLESPHSLPAK#LPGGVQNFPQFSALR.F |
| Matching Proteins |
|
| Site Position | 281 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.FLVVTQK#AAFTCIK.N |
| Matching Proteins |
|
| Site Position | 329 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.EK#EGSRGEEDTGQEEGGSR.R |
| Matching Proteins |
|
| Site Position | 642 |
|---|---|
| MS/MS spectra | 8 [show] |
| Best localized sequence | R.AQMTK#YLQSNSNNWR@.W |
| Matching Proteins |
|
| Site Position | 727 |
|---|---|
| MS/MS spectra | 6 [show] |
| Best localized sequence | K.NSK#NSNGQELEK.T |
| Matching Proteins |
|
| Site Position | 736 |
|---|---|
| MS/MS spectra | 9 [show] |
| Best localized sequence | K.NSNGQELEK#TLEESK.E |
| Matching Proteins |
|
| Site Position | 742 |
|---|---|
| MS/MS spectra | 10 [show] |
| Best localized sequence | K.TLEESK#EMDIK.R |
| Matching Proteins |
|
| Site Position | 752 |
|---|---|
| MS/MS spectra | 16 [show] |
| Best localized sequence | K.ENK#GNDTPLALESTNTEK.E |
| Matching Proteins |
|
| Site Position | 767 |
|---|---|
| MS/MS spectra | 128 [show] |
| Best localized sequence | K.GNDTPLALESTNTEK#ETSLEETK.I |
| Matching Proteins |
|
| Site Position | 833 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.YAMMFAELK#STR@.M |
| Matching Proteins |
|
| Site Position | 874 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.HTMEK#VVR.S |
| Matching Proteins |
|
| Site Position | 951 |
|---|---|
| MS/MS spectra | 41 [show] |
| Best localized sequence | R.IK#GPNAVQLVK.T |
| Matching Proteins |
|
| Site Position | 960 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | K.GPNAVQLVK#TTPLKPSPLPVIPDTIK.E |
| Matching Proteins |
|
| Site Position | 965 |
|---|---|
| MS/MS spectra | 112 [show] |
| Best localized sequence | K.TTPLK#PSPLPVIPDTIK.E |
| Matching Proteins |
|
| Site Position | 1252 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.LFLK#K#GLVNDLAR@.V |
| Matching Proteins |
|
| Site Position | 1253 |
|---|---|
| MS/MS spectra | 3 [show] |
| Best localized sequence | R.LFLK#K#GLVNDLAR@.V |
| Matching Proteins |
|
| Site Position | 1282 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | R.VPHSLDLSSPNMANTVNAALK#PLETLSR.I |
| Matching Proteins |
|
| Site Position | 1301 |
|---|---|
| MS/MS spectra | 34 [show] |
| Best localized sequence | R.IVNQPSSLFGSK#SASSK.N |
| Matching Proteins |
|
| Site Position | 1729 |
|---|---|
| MS/MS spectra | 21 [show] |
| Best localized sequence | R.K#QLAEEETK.I |
| Matching Proteins |
|
| Site Position | 1737 |
|---|---|
| MS/MS spectra | 16 [show] |
| Best localized sequence | K.QLAEEETK#ITDK.G |
| Matching Proteins |
|
| Site Position | 2278 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.SSESELCIETPK#LTTSEEK.G |
| Matching Proteins |
|
| Site Position | 2379 |
|---|---|
| MS/MS spectra | 95 [show] |
| Best localized sequence | R.HVLDTLIQLAK#VFPSHFTQQR.T |
| Matching Proteins |
|
| Site Position | 2486 |
|---|---|
| MS/MS spectra | 60 [show] |
| Best localized sequence | R.SSLLTEK#LLR@.L |
| Matching Proteins |
|
| Site Position | 2592 |
|---|---|
| MS/MS spectra | 104 [show] |
| Best localized sequence | K.SPAK#VSDGGSSSTDFK.M |
| Matching Proteins |
|
| Site Position | 2655 |
|---|---|
| MS/MS spectra | 8 [show] |
| Best localized sequence | R.DTVLK#LLLNGAR.H |
| Matching Proteins |
|
| Site Position | 2670 |
|---|---|
| MS/MS spectra | 4 [show] |
| Best localized sequence | R.HLGYTLCK#QIGTLLAELR@.E |
| Matching Proteins |
|
| Site Position | 2731 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.FDMAENVVIVASQK#RPLGGR.E |
| Matching Proteins |
|
| Site Position | 2869 |
|---|---|
| MS/MS spectra | 4 [show] |
| Best localized sequence | R.REESPMDVDQPSPSAQDTQSIASDGTPQGEK#EK.E |
| Matching Proteins |
|
| Site Position | 2946 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | R.ESQLAHIK#DEPPPLSPAPLTPATPSSLDPFFSR.E |
| Matching Proteins |
|
| Site Position | 3150 |
|---|---|
| MS/MS spectra | 11 [show] |
| Best localized sequence | R.IVAK#AVYDNR.L |
| Matching Proteins |
|
| Site Position | 3224 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.DLK#PNGANILVTEENKK.E |
| Matching Proteins |
|
| Site Position | 3329 |
|---|---|
| MS/MS spectra | 3 [show] |
| Best localized sequence | R.AK#FLQFVTGTSK.V |
| Matching Proteins |
|