IPI:IPI00456919.2
Protein Information
| Protein | IPI:IPI00456919.2 |
|---|---|
| Gene Symbol | HUWE1 |
| Protein Description | Isoform 1 of E3 ubiquitin-protein ligase HUWE1 |
| Sequence Length | 4374 |
| Mwt | 481588.655 Da |
| Sequence | MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT TLLASSDMQV VLAVLNLLYV FSKRSNYITR LGSDKRTPLL TRLQHLAESW GGKENGFGLA ECCRDLHMMK YPPSATTLHF EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM ESLTKMYSIP KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT GTASYHGFLP VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG EALVSCGMME ALLKVIKFLG DEQDQITFVT RAVRVVDLIT NLDMAAFQSH SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ RPNTTQEGEE METDMDGVQC IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL KHIISNAEYY GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD PLGDTASNLG SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ KPSIQKADGT ATAPPPRSNH AAEEASSEDE EEEEVQAMQS FNSTQQNETE PNQQVVGTEE RIPIPLMDYI LNVMKFVESI LSNNTTDDHC QEFVNQKGLL PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV LQEGLLQLDS ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV LLSLCTPNSL PSGCEFGQAD MQKLVPKDEK AGTTQGGKRS DGEQDGAAGS MDASTQGLLE GIGLDGDTLA PMETDEPTAS DSKGKSKITP AMAARIKQIK PLLSASSRLG RALAELFGLL VKLCVGSPVR QRRSHHAAST TTAPTPAARS TASALTKLLT KGLSWQPPPY TPTPRFRLTF FICSVGFTSP MLFDERKYPY HLMLQKFLCS GGHNALFETF NWALSMGGKV PVSEGLEHSD LPDGTGEFLD AWLMLVEKMV NPTTVLESPH SLPAKLPGGV QNFPQFSALR FLVVTQKAAF TCIKNLWNRK PLKVYGGRMA ESMLAILCHI LRGEPVIRER LSKEKEGSRG EEDTGQEEGG SRREPQVNQQ QLQQLMDMGF TREHAMEALL NTSTMEQATE YLLTHPPPIM GGVVRDLSMS EEDQMMRAIA MSLGQDIPMD QRAESPEEVA CRKEEEERKA REKQEEEEAK CLEKFQDADP LEQDELHTFT DTMLPGCFHL LDELPDTVYR VCDLIMTAIK RNGADYRDMI LKQVVNQVWE AADVLIKAAL PLTTSDTKTV SEWISQMATL PQASNLATRI LLLTLLFEEL KLPCAWVVES SGILNVLIKL LEVVQPCLQA AKEQKEVQTP KWITPVLLLI DFYEKTAISS KRRAQMTKYL QSNSNNWRWF DDRSGRWCSY SASNNSTIDS AWKSGETSVR FTAGRRRYTV QFTTMVQVNE ETGNRRPVML TLLRVPRLNK NSKNSNGQEL EKTLEESKEM DIKRKENKGN DTPLALESTN TEKETSLEET KIGEILIQGL TEDMVTVLIR ACVSMLGVPV DPDTLHATLR LCLRLTRDHK YAMMFAELKS TRMILNLTQS SGFNGFTPLV TLLLRHIIED PCTLRHTMEK VVRSAATSGA GSTTSGVVSG SLGSREINYI LRVLGPAACR NPDIFTEVAN CCIRIALPAP RGSGTASDDE FENLRIKGPN AVQLVKTTPL KPSPLPVIPD TIKEVIYDML NALAAYHAPE EADKSDPKPG VMTQEVGQLL QDMGDDVYQQ YRSLTRQSSD FDTQSGFSIN SQVFAADGAS TETSASGTSQ GEASTPEESR DGKKDKEGDR ASEEGKQKGK GSKPLMPTST ILRLLAELVR SYVGIATLIA NYSYTVGQSE LIKEDCSVLA FVLDHLLPHT QNAEDKDTPA LARLFLASLA AAGSGTDAQV ALVNEVKAAL GRALAMAEST EKHARLQAVM CIISTIMESC PSTSSFYSSA TAKTQHNGMN NIIRLFLKKG LVNDLARVPH SLDLSSPNMA NTVNAALKPL ETLSRIVNQP SSLFGSKSAS SKNKSEQDAQ GASQDSSSNQ QDPGEPGEAE VQEEDHDVTQ TEVADGDIMD GEAETDSVVI AGQPEVLSSQ EMQVENELED LIDELLERDG GSGNSTIIVS RSGEDESQED VLMDEAPSNL SQASTLQANR EDSMNILDPE DEEEHTQEED SSGSNEDEDD SQDEEEEEEE DEEDDQEDDE GEEGDEDDDD DGSEMELDED YPDMNASPLV RFERFDREDD LIIEFDNMFS SATDIPPSPG NIPTTHPLMV RHADHSSLTL GSGSSTTRLT QGIGRSQRTL RQLTANTGHT IHVHYPGNRQ PNPPLILQRL LGPSAAADIL QLSSSLPLQS RGRARLLVGN DDVHIIARSD DELLDDFFHD QSTATSQAGT LSSIPTALTR WTEECKVLDA ESMHDCVSVV KVSIVNHLEF LRDEELEERR EKRRKQLAEE ETKITDKGKE DKENRDQSAQ CTASKSNDST EQNLSDGTPM PDSYPTTPSS TDAATSESKE TLGTLQSSQQ QPTLPTPPAL GEVPQELQSP AGEGGSSTQL LMPVEPEELG PTRPSGEAET TQMELSPAPT ITSLSPERAE DSDALTAVSS QLEGSPMDTS SLASCTLEEA VGDTSAAGSS EQPRAGSSTP GDAPPAVAEV QGRSDGSGES AQPPEDSSPP ASSESSSTRD SAVAISGADS RGILEEPLPS TSSEEEDPLA GISLPEGVDP SFLAALPDDI RREVLQNQLG IRPPTRTAPS TNSSAPAVVG NPGVTEVSPE FLAALPPAIQ EEVLAQQRAE QQRRELAQNA SSDTPMDPVT FIQTLPSDLR RSVLEDMEDS VLAVMPPDIA AEAQALRREQ EARQRQLMHE RLFGHSSTSA LSAILRSPAF TSRLSGNRGV QYTRLAVQRG GTFQMGGSSS HNRPSGSNVD TLLRLRGRLL LDHEALSCLL VLLFVDEPKL NTSRLHRVLR NLCYHAQTRH WVIRSLLSIL QRSSESELCI ETPKLTTSEE KGKKSSKSCG SSSHENRPLD LLHKMESKSS NQLSWLSVSM DAALGCRTNI FQIQRSGGRK HTEKHASGGS TVHIHPQAAP VVCRHVLDTL IQLAKVFPSH FTQQRTKETN CESDRERGNK ACSPCSSQSS SSGICTDFWD LLVKLDNMNV SRKGKNSVKS VPVSAGGEGE TSPYSLEASP LGQLMNMLSH PVIRRSSLLT EKLLRLLSLI SIALPENKVS EAQANSGSGA SSTTTATSTT STTTTTAAST TPTPPTAPTP VTSAPALVAA TAISTIVVAA STTVTTPTTA TTTVSISPTT KGSKSPAKVS DGGSSSTDFK MVSSGLTENQ LQLSVEVLTS HSCSEEGLED AANVLLQLSR GDSGTRDTVL KLLLNGARHL GYTLCKQIGT LLAELREYNL EQQRRAQCET LSPDGLPEEQ PQTTKLKGKM QSRFDMAENV VIVASQKRPL GGRELQLPSM SMLTSKTSTQ KFFLRVLQVI IQLRDDTRRA NKKAKQTGRL GSSGLGSASS IQAAVRQLEA EADAIIQMVR EGQRARRQQQ AATSESSQSE ASVRREESPM DVDQPSPSAQ DTQSIASDGT PQGEKEKEER PPELPLLSEQ LSLDELWDML GECLKELEES HDQHAVLVLQ PAVEAFFLVH ATERESKPPV RDTRESQLAH IKDEPPPLSP APLTPATPSS LDPFFSREPS SMHISSSLPP DTQKFLRFAE THRTVLNQIL RQSTTHLADG PFAVLVDYIR VLDFDVKRKY FRQELERLDE GLRKEDMAVH VRRDHVFEDS YRELHRKSPE EMKNRLYIVF EGEEGQDAGG LLREWYMIIS REMFNPMYAL FRTSPGDRVT YTINPSSHCN PNHLSYFKFV GRIVAKAVYD NRLLECYFTR SFYKHILGKS VRYTDMESED YHFYQGLVYL LENDVSTLGY DLTFSTEVQE FGVCEVRDLK PNGANILVTE ENKKEYVHLV CQMRMTGAIR KQLAAFLEGF YEIIPKRLIS IFTEQELELL ISGLPTIDID DLKSNTEYHK YQSNSIQIQW FWRALRSFDQ ADRAKFLQFV TGTSKVPLQG FAALEGMNGI QKFQIHRDDR STDRLPSAHT CFNQLDLPAY ESFEKLRHML LLAIQECSEG FGLA |
Modification Site Information
| Site Position | 674 |
|---|---|
| MS/MS spectra | 20 [show] |
| Best localized sequence | R.HQPTLK#TDATTAIIK.L |
| Matching Proteins |
|
| Site Position | 1107 |
|---|---|
| MS/MS spectra | 14 [show] |
| Best localized sequence | R.STASALTK#LLTK.G |
| Matching Proteins |
|
| Site Position | 1111 |
|---|---|
| MS/MS spectra | 18 [show] |
| Best localized sequence | K.LLTK#GLSWQPPPYTPTPR.F |
| Matching Proteins |
|
| Site Position | 1225 |
|---|---|
| MS/MS spectra | 5 [show] |
| Best localized sequence | K.MVNPTTVLESPHSLPAK#LPGGVQNFPQFSALR.F |
| Matching Proteins |
|
| Site Position | 1247 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.FLVVTQK#AAFTCIK.N |
| Matching Proteins |
|
| Site Position | 1295 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.EK#EGSRGEEDTGQEEGGSR.R |
| Matching Proteins |
|
| Site Position | 1608 |
|---|---|
| MS/MS spectra | 8 [show] |
| Best localized sequence | R.AQMTK#YLQSNSNNWR@.W |
| Matching Proteins |
|
| Site Position | 1693 |
|---|---|
| MS/MS spectra | 6 [show] |
| Best localized sequence | K.NSK#NSNGQELEK.T |
| Matching Proteins |
|
| Site Position | 1702 |
|---|---|
| MS/MS spectra | 9 [show] |
| Best localized sequence | K.NSNGQELEK#TLEESK.E |
| Matching Proteins |
|
| Site Position | 1708 |
|---|---|
| MS/MS spectra | 10 [show] |
| Best localized sequence | K.TLEESK#EMDIK.R |
| Matching Proteins |
|
| Site Position | 1718 |
|---|---|
| MS/MS spectra | 16 [show] |
| Best localized sequence | K.ENK#GNDTPLALESTNTEK.E |
| Matching Proteins |
|
| Site Position | 1733 |
|---|---|
| MS/MS spectra | 128 [show] |
| Best localized sequence | K.GNDTPLALESTNTEK#ETSLEETK.I |
| Matching Proteins |
|
| Site Position | 1799 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | K.YAMMFAELK#STR@.M |
| Matching Proteins |
|
| Site Position | 1840 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.HTMEK#VVR.S |
| Matching Proteins |
|
| Site Position | 1917 |
|---|---|
| MS/MS spectra | 41 [show] |
| Best localized sequence | R.IK#GPNAVQLVK.T |
| Matching Proteins |
|
| Site Position | 1926 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | K.GPNAVQLVK#TTPLKPSPLPVIPDTIK.E |
| Matching Proteins |
|
| Site Position | 1931 |
|---|---|
| MS/MS spectra | 112 [show] |
| Best localized sequence | K.TTPLK#PSPLPVIPDTIK.E |
| Matching Proteins |
|
| Site Position | 2218 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.LFLK#K#GLVNDLAR@.V |
| Matching Proteins |
|
| Site Position | 2219 |
|---|---|
| MS/MS spectra | 3 [show] |
| Best localized sequence | R.LFLK#K#GLVNDLAR@.V |
| Matching Proteins |
|
| Site Position | 2248 |
|---|---|
| MS/MS spectra | 7 [show] |
| Best localized sequence | R.VPHSLDLSSPNMANTVNAALK#PLETLSR.I |
| Matching Proteins |
|
| Site Position | 2267 |
|---|---|
| MS/MS spectra | 34 [show] |
| Best localized sequence | R.IVNQPSSLFGSK#SASSK.N |
| Matching Proteins |
|
| Site Position | 2695 |
|---|---|
| MS/MS spectra | 21 [show] |
| Best localized sequence | R.K#QLAEEETK.I |
| Matching Proteins |
|
| Site Position | 2703 |
|---|---|
| MS/MS spectra | 16 [show] |
| Best localized sequence | K.QLAEEETK#ITDK.G |
| Matching Proteins |
|
| Site Position | 3244 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.SSESELCIETPK#LTTSEEK.G |
| Matching Proteins |
|
| Site Position | 3345 |
|---|---|
| MS/MS spectra | 95 [show] |
| Best localized sequence | R.HVLDTLIQLAK#VFPSHFTQQR.T |
| Matching Proteins |
|
| Site Position | 3452 |
|---|---|
| MS/MS spectra | 60 [show] |
| Best localized sequence | R.SSLLTEK#LLR@.L |
| Matching Proteins |
|
| Site Position | 3558 |
|---|---|
| MS/MS spectra | 104 [show] |
| Best localized sequence | K.SPAK#VSDGGSSSTDFK.M |
| Matching Proteins |
|
| Site Position | 3621 |
|---|---|
| MS/MS spectra | 8 [show] |
| Best localized sequence | R.DTVLK#LLLNGAR.H |
| Matching Proteins |
|
| Site Position | 3636 |
|---|---|
| MS/MS spectra | 4 [show] |
| Best localized sequence | R.HLGYTLCK#QIGTLLAELR@.E |
| Matching Proteins |
|
| Site Position | 3697 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.FDMAENVVIVASQK#RPLGGR.E |
| Matching Proteins |
|
| Site Position | 3835 |
|---|---|
| MS/MS spectra | 4 [show] |
| Best localized sequence | R.REESPMDVDQPSPSAQDTQSIASDGTPQGEK#EK.E |
| Matching Proteins |
|
| Site Position | 3912 |
|---|---|
| MS/MS spectra | 2 [show] |
| Best localized sequence | R.ESQLAHIK#DEPPPLSPAPLTPATPSSLDPFFSR.E |
| Matching Proteins |
|
| Site Position | 4116 |
|---|---|
| MS/MS spectra | 11 [show] |
| Best localized sequence | R.IVAK#AVYDNR.L |
| Matching Proteins |
|
| Site Position | 4190 |
|---|---|
| MS/MS spectra | 1 [show] |
| Best localized sequence | R.DLK#PNGANILVTEENKK.E |
| Matching Proteins |
|
| Site Position | 4295 |
|---|---|
| MS/MS spectra | 3 [show] |
| Best localized sequence | R.AK#FLQFVTGTSK.V |
| Matching Proteins |
|